In Vitro Cellular and Developmental Biology Journal = Highlights

From: Subject: In Vitro Cellular and Developmental Biology Journal Highlights Date: Fri, 29 Feb 2008 11:40:57 -0500 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C87AC7.F32025B0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C87AC7.F32025B0 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.sivb.org/journalHighlights41-4.asp In Vitro Cellular and Developmental Biology Journal = Highlights

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Journal Highlights, 41-4

Specialty plants biotechnology group at = ARS,=20 FVSU. Left to right: Dr. Nirmal Joshee (Research = Professional), Sadanand Dhekney (Ph.D. student = India)=20 and Dr. Anand K. Yadav (Professor).=20

The tropical fruit biotechnology = research=20 group at the UF TREC. From left to right: Dr. = Simon=20 Raharjo (post doctoral scientist Indonesia), = Darda=20 Efendi (Ph.D. student Indonesia), Isidro Suarez = (Ph.D.=20 student Colombia), Sadanand Dhekney (Ph.D. = student=20 India), Pamela Moon (senior biologist) and = Professor=20 Richard Litz. =

Potential for = Introducing=20 Cold Tolerance into Papaya by Transformation with = C-Repeat=20 Binding Factor (CBF) Genes

This project was undertaken as a joint project = between the=20 groups at the University of Florida (UF TREC) and Fort = Valley=20 State University (FVSU). The idea for this research = was to=20 extend the range of a tropical fruit species papaya = into the=20 warm temperate zone of north Florida and south = Georgia.=20 Because of the absence of cold tolerance in papaya = Carica=20 papaya L., a proposal was developed that would 1) = probe the=20 genome of papaya and its cold-tolerant Andean = relatives in the=20 genus Vasconcellea for CBF (C-repeat binding factor) = genes and=20 2) carry out genetic transformation of papaya with CBF = genes.=20 Michael Thomashow and his co-workers have = characterized CBF=20 genes as transcriptional activators that bind to the = promoter=20 regions of cold tolerance genes. Overexpression of CBF = genes=20 in Arabidopsis results in activation of cold-regulated = (COR)=20 genes, and has been linked with improved chilling = tolerance.=20 The University of Florida laboratory at Homestead, at = the=20 southernmost tip of Florida, has focused on tropical = fruit=20 biotechnology for several years, and has considerable=20 experience working with several species in addition to = papaya,=20 including mango, avocado, litchi, carambola and = longan. The=20 FVSU research emphasizes biotechnology to enhance cold = hardiness in peach, papaya and guava and selected = medicinal=20 plants. Sadanand Dhekney, who completed a M.S. degree = at the=20 Tamil Nadu Agricultural University in Coimbatore, = India, was=20 recruited as a Ph.D. student at the University of = Florida to=20 work on this project. Sadanand determined that DNA = sequences=20 bearing homology to the CBF gene, although present in = the=20 cold-tolerant Vascaoncellea species, were missing in = papaya.=20 He developed a genetic transformation procedure for = papaya=20 based upon the co-cultivation of embryogenic cultures = with=20 genetically engineered Agrobacterium tumefaciens = strain GV3101=20 that contained the CBF gene(s) under the control of = the CaMV=20 35S promoter and the NPTII gene under the control of = the CaMV=20 35S promoter. Embryogenic papaya cultures were = successfully=20 transformed, and plants were recovered. Regenerants = are=20 currently under evaluation. Sadanand A. Dhekney, = Richard=20 E. Litz, David A. Moraga and Anand Y. Yadav. = Potential for=20 introducing cold tolerance into papaya by = transformation with=20 c-repeat binding factor (CBF) genes, In Vitro = Cellular=20 & Developmental Biology-Plant, 43: in=20 production.

Left to right: Touho = Yoshida,=20 Kazumi Ono, Motonobu Satoh, Hidekazu Sawada.=20

Nested PCR to Identify 14 = Species of=20 Animal Cells

It has been occasionally reported that cell lines = derived=20 from a certain source can be contaminated with another = cell=20 line. This cross-culture contamination is a serious = problem=20 for investigations using cultured cells. Therefore, it = is very=20 important to confirm the identities of cell lines as a = quality=20 control. So, we developed a highly sensitive and = convenient=20 method of nested polymerase chain reaction (PCR) = targeted to=20 mitochondrial DNA to identify animal species quickly = in=20 cultured cells. Fourteen vertebrate species, including = human,=20 cynomolgus monkey, African green monkey, mouse, rat, = Syrian=20 hamster, Chinese hamster, guinea pig, rabbit, dog, = cat, cow,=20 pig and chicken, could be distinguished from each = other by=20 nested PCR. The 1st PCR amplifies mitochondrial DNA = fragments=20 with a universal primer pair complementary to the = conserved=20 regions of 14 species, and the 2nd PCR amplifies the = DNA=20 fragments with species-specific primer pairs from the = 1st=20 products. The species-specific primer pairs were = designed to=20 easily distinguish 14 species from each other under = standard=20 agarose gel electrophoresis. We further developed the=20 multiplex PCR using a mixture of seven = species-specific primer=20 pairs for two groups of animals. One was comprised of = human,=20 mouse, rat, cat, pig, cow, and rabbit and the other = was=20 comprised of African green monkey, cynomolgus monkey, = Syrian=20 hamster, Chinese hamster, guinea pig, dog, and = chicken. The=20 sensitivity of the PCR assay was at least 100 pg = DNA/reaction,=20 which was sufficient for the detection of each species = DNA.=20 Furthermore, the nested PCR method was able to = identify the=20 species in the interspecies mixture of DNA. Thus the = method=20 developed in this study will provide a useful tool for = the=20 authentication of animal species. Kazumi Ono, = Motonobu=20 Satoh, Touho Yoshida, Yutaka Ozawa, Arihiro = Kohara, Masao=20 Takeuchi, Hiroshi Mizusawa, and Hidekazu Sawada.=20 Species Identification of Animal Cells by Nested = PCR=20 Targeted to Mitochondrial DNA, In Vitro Cellular = and=20 Developmental Biology - Animal 43: 168-175, = 2007.

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royalty free license to use or modify this * software provided that this copyright notice appears on all copies. * This software is provided "AS IS," without a warranty of any kind. */ function Menu(label, mw, mh, fnt, fs, fclr, fhclr, bg, bgh) { this.version =3D "990702 [Menu; menu.js]"; this.type =3D "Menu"; this.menuWidth =3D mw; this.menuItemHeight =3D mh; this.fontSize =3D fs||12; this.fontWeight =3D "plain"; this.fontFamily =3D fnt||"arial,helvetica,verdana,sans-serif"; this.fontColor =3D fclr||"#000000"; this.fontColorHilite =3D fhclr||"#ffffff"; this.bgColor =3D "#3333CC"; this.menuBorder =3D 0; this.menuItemBorder =3D 1; this.menuItemBgColor =3D bg||"#cccccc"; this.menuLiteBgColor =3D "#ffffff"; this.menuBorderBgColor =3D "#777777"; this.menuHiliteBgColor =3D bgh||"#000084"; this.menuContainerBgColor =3D "#cccccc"; this.childMenuIcon =3D "arrows.gif"; this.items =3D new Array(); this.actions =3D new Array(); this.childMenus =3D new Array(); this.hideOnMouseOut =3D true; this.addMenuItem =3D addMenuItem; this.addMenuSeparator =3D addMenuSeparator; this.writeMenus =3D writeMenus; this.FW_showMenu =3D FW_showMenu; this.onMenuItemOver =3D onMenuItemOver; this.onMenuItemAction =3D onMenuItemAction; this.hideMenu =3D hideMenu; this.hideChildMenu =3D hideChildMenu; if (!window.menus) window.menus =3D new Array(); this.label =3D label || "menuLabel" + window.menus.length; window.menus[this.label] =3D this; window.menus[window.menus.length] =3D this; if (!window.activeMenus) window.activeMenus =3D new Array(); } function addMenuItem(label, action) { this.items[this.items.length] =3D label; this.actions[this.actions.length] =3D action; } function addMenuSeparator() { this.items[this.items.length] =3D "separator"; this.actions[this.actions.length] =3D ""; this.menuItemBorder =3D 0; } // For NS6.=20 function FIND(item) { if (document.all) return(document.all[item]); if (document.getElementById) return(document.getElementById(item)); return(false); } function writeMenus(container) { if (window.triedToWriteMenus) return; if (!container && document.layers) { window.delayWriteMenus =3D this.writeMenus; var timer =3D setTimeout('delayWriteMenus()', 250); container =3D new Layer(100); clearTimeout(timer); } else if (document.all || document.hasChildNodes) { document.writeln(''); container =3D FIND("menuContainer"); } window.fwHideMenuTimer =3D null; if (!container) return;=09 window.triedToWriteMenus =3D true;=20 container.isContainer =3D true; container.menus =3D new Array(); for (var i=3D0; i\n'+ '

\n'+ '

\n'+ ''; } var x=3Di; for (var i=3D0; i'; var dClose =3D '

' if (menu.bgImageUp) { menu.menuBorder =3D 0; menu.menuItemBorder =3D 0; dTag =3D '

'; if (document.layers) { dTag =3D ''; dClose =3D ''; } } var textProps =3D 'position:absolute;left:' + menu.menuItemIndent + = ';top:1;'; if (lrs) { textProps +=3DitemProps; dTag =3D ""; dClose =3D ""; } var dText =3D '

'+ item +'

'+ item = +'

'; if (item =3D=3D "separator") { content +=3D ( dTag + '

\n' + dClose); } else if (childMenu) { content +=3D ( dTag + dText + '

\n' + dClose); } else { content +=3D ( dTag + dText + dClose); } if (lrs) { l.document.open("text/html"); l.document.writeln(content); l.document.close();=09 content =3D ''; theStat +=3D "-"; tsc++; if (tsc > 50) { tsc =3D 0; theStat =3D ""; } status =3D theStat; } countItems++; =20 } if (lrs) { // focus layer var focusItem =3D new Layer(100, body); focusItem.visiblity=3D"hidden"; focusItem.document.open("text/html"); focusItem.document.writeln(" "); focusItem.document.close();=09 } else { content +=3D '

\n'; content +=3D '

\n\n'; } i=3Dx; } if (document.layers) { =09 container.clip.width =3D window.innerWidth; container.clip.height =3D window.innerHeight; container.onmouseout =3D mouseoutMenu; container.menuContainerBgColor =3D this.menuContainerBgColor; for (var i=3D0; i0) l.top =3D body.document.layers[n-1].top + = body.document.layers[n-1].clip.height + proto.menuItemBorder; l.hilite =3D l.document.layers[1]; if (proto.bgImageUp) l.background.src =3D proto.bgImageUp; l.document.layers[1].isHilite =3D true; if (l.document.layers[0].id.indexOf("menuSeparator") !=3D -1) { l.hilite =3D null; l.clip.height -=3D l.clip.height / 2; l.document.layers[0].document.bgColor =3D proto.bgColor; l.document.layers[0].clip.width =3D l.clip.width -2; l.document.layers[0].clip.height =3D 1; l.document.layers[1].document.bgColor =3D proto.menuLiteBgColor; l.document.layers[1].clip.width =3D l.clip.width -2; l.document.layers[1].clip.height =3D 1; l.document.layers[1].top =3D l.document.layers[0].top + 1; } else if (l.document.layers.length > 2) { l.childMenu =3D container.menus[i].items[n].menuLayer; l.document.layers[2].left =3D l.clip.width -13; l.document.layers[2].top =3D (l.clip.height / 2) -4; l.document.layers[2].clip.left +=3D 3; l.Menu.childMenus[l.Menu.childMenus.length] =3D l.childMenu; } } body.document.bgColor =3D proto.bgColor; body.clip.width =3D l.clip.width +proto.menuBorder; body.clip.height =3D l.top + l.clip.height +proto.menuBorder; var focusItem =3D body.document.layers[n]; focusItem.clip.width =3D body.clip.width; focusItem.Menu =3D l.Menu; focusItem.top =3D -30; focusItem.captureEvents(Event.MOUSEDOWN); focusItem.onmousedown =3D onMenuItemDown; menu.document.bgColor =3D proto.menuBorderBgColor; var lite =3D menu.document.layers[0]; lite.document.bgColor =3D proto.menuLiteBgColor; lite.clip.width =3D body.clip.width +1; lite.clip.height =3D body.clip.height +1; menu.clip.width =3D body.clip.width + (proto.menuBorder * 3) ; menu.clip.height =3D body.clip.height + (proto.menuBorder * 3); } } else { if ((!document.all) && (container.hasChildNodes)) { container.innerHTML=3Dcontent; } else { container.document.open("text/html"); container.document.writeln(content); container.document.close();=09 } if (!FIND("menuLayer0")) return; var menuCount =3D 0; for (var x=3D0; x window.innerWidth ||=20 NS4sIH > window.innerHeight ||=20 NS4sIH < window.innerHeight )=20 { window.location.reload(); } } function onMenuItemOver(e, l) { FW_clearTimeout(); l =3D l || this; a =3D window.ActiveMenuItem; if (document.layers) { if (a) { a.document.bgColor =3D a.saveColor; if (a.hilite) a.hilite.visibility =3D "hidden"; if (a.Menu.bgImageOver) { a.background.src =3D a.Menu.bgImageUp; } a.focusItem.top =3D -100; a.clicked =3D false; } if (l.hilite) { l.document.bgColor =3D l.menuHiliteBgColor; l.zIndex =3D 1; l.hilite.visibility =3D "inherit"; l.hilite.zIndex =3D 2; l.document.layers[1].zIndex =3D 1; l.focusItem.zIndex =3D this.zIndex +2; } if (l.Menu.bgImageOver) { l.background.src =3D l.Menu.bgImageOver; } l.focusItem.top =3D this.top; l.Menu.hideChildMenu(l); } else if (l.style && l.Menu) { if (a) { a.style.backgroundColor =3D a.saveColor; if (a.hilite) a.hilite.style.visibility =3D "hidden"; if (a.Menu.bgImageUp) { a.style.background =3D "url(" + a.Menu.bgImageUp +")";; } }=20 if (l.isSeparator) return; l.style.backgroundColor =3D l.menuHiliteBgColor; l.zIndex =3D 1; // magic IE 4.5 mac happy doohicky. jba if (l.Menu.bgImageOver) { l.style.background =3D "url(" + l.Menu.bgImageOver +")"; } if (l.hilite) { l.style.backgroundColor =3D l.menuHiliteBgColor; l.hilite.style.visibility =3D "inherit"; } l.focusItem.style.top =3D l.focusItem.style.pixelTop =3D = l.style.pixelTop; l.focusItem.style.zIndex =3D l.zIndex +1; l.Menu.hideChildMenu(l); } else { return; // not a menu - magic IE 4.5 mac happy doohicky. jba } window.ActiveMenuItem =3D l; } function onMenuItemAction(e, l) { l =3D window.ActiveMenuItem; if (!l) return; hideActiveMenus(); if (l.action) { eval("" + l.action); } window.ActiveMenuItem =3D 0; } function FW_clearTimeout() { if (fwHideMenuTimer) clearTimeout(fwHideMenuTimer); fwHideMenuTimer =3D null; fwDHFlag =3D false; } function FW_startTimeout() { fwStart =3D new Date(); fwDHFlag =3D true; fwHideMenuTimer =3D setTimeout("fwDoHide()", 1000); } function fwDoHide() { if (!fwDHFlag) return; var elapsed =3D new Date() - fwStart; if (elapsed < 500) { fwHideMenuTimer =3D setTimeout("fwDoHide()", 500-elapsed); return; } fwDHFlag =3D false; hideActiveMenus(); window.ActiveMenuItem =3D 0; } function FW_showMenu(menu, x, y, child) { if (!window.fwWroteMenu) return; FW_clearTimeout(); if (document.layers) { if (menu) { var l =3D menu.menuLayer || menu; l.left =3D 1; l.top =3D 1; hideActiveMenus(); if (this.visibility) l =3D this; window.ActiveMenu =3D l; } else { var l =3D child; } if (!l) return; for (var i=3D0; i 0)=20 FW_showMenu(null, "relative", "relative", l.layers[i]); } if (l.parentLayer) { if (x !=3D "relative")=20 l.parentLayer.left =3D x || window.pageX || 0; if (l.parentLayer.left + l.clip.width > window.innerWidth)=20 l.parentLayer.left -=3D (l.parentLayer.left + l.clip.width - = window.innerWidth); if (y !=3D "relative")=20 l.parentLayer.top =3D y || window.pageY || 0; if (l.parentLayer.isContainer) { l.Menu.xOffset =3D window.pageXOffset; l.Menu.yOffset =3D window.pageYOffset; l.parentLayer.clip.width =3D window.ActiveMenu.clip.width +2; l.parentLayer.clip.height =3D window.ActiveMenu.clip.height +2; if (l.parentLayer.menuContainerBgColor) = l.parentLayer.document.bgColor =3D l.parentLayer.menuContainerBgColor; } } l.visibility =3D "inherit"; if (l.Menu) l.Menu.container.visibility =3D "inherit"; } else if (FIND("menuItem0")) { var l =3D menu.menuLayer || menu;=09 hideActiveMenus(); if (typeof(l) =3D=3D "string") { l =3D FIND(l); } window.ActiveMenu =3D l; var s =3D l.style; s.visibility =3D "inherit"; if (x !=3D "relative")=20 s.left =3D s.pixelLeft =3D x || (window.pageX + = document.body.scrollLeft) || 0; if (y !=3D "relative")=20 s.top =3D s.pixelTop =3D y || (window.pageY + = document.body.scrollTop) || 0; l.Menu.xOffset =3D document.body.scrollLeft; l.Menu.yOffset =3D document.body.scrollTop; } if (menu) { window.activeMenus[window.activeMenus.length] =3D l; } } function onMenuItemDown(e, l) { var a =3D window.ActiveMenuItem; if (document.layers) { if (a) { a.eX =3D e.pageX; a.eY =3D e.pageY; a.clicked =3D true; } } } function mouseupMenu(e) { hideMenu(true, e); hideActiveMenus(); return true; } function mouseoutMenu() { hideMenu(false, false); return true; } function hideMenu(mouseup, e) { var a =3D window.ActiveMenuItem; if (a && document.layers) { a.document.bgColor =3D a.saveColor; a.focusItem.top =3D -30; if (a.hilite) a.hilite.visibility =3D "hidden"; if (mouseup && a.action && a.clicked && window.ActiveMenu) { if (a.eX <=3D e.pageX+15 && a.eX >=3D e.pageX-15 && a.eY <=3D = e.pageY+10 && a.eY >=3D e.pageY-10) { setTimeout('window.ActiveMenu.Menu.onMenuItemAction();', 2); } } a.clicked =3D false; if (a.Menu.bgImageOver) { a.background.src =3D a.Menu.bgImageUp; } } else if (window.ActiveMenu && FIND("menuItem0")) { if (a) { a.style.backgroundColor =3D a.saveColor; if (a.hilite) a.hilite.style.visibility =3D "hidden"; if (a.Menu.bgImageUp) { a.style.background =3D "url(" + a.Menu.bgImageUp +")";; } } } if (!mouseup && window.ActiveMenu) { if (window.ActiveMenu.Menu) { if (window.ActiveMenu.Menu.hideOnMouseOut) { FW_startTimeout(); } return(true); } } return(true); } function PxToNum(pxStr) { // pxStr =3D=3D 27px, we want 27. if (pxStr.length > 2) { n =3D Number(pxStr.substr(0, pxStr.length-2)); return(n); } return(0); } function hideChildMenu(hcmLayer) { FW_clearTimeout(); var l =3D hcmLayer; for (var i=3D0; i < l.Menu.childMenus.length; i++) { var theLayer =3D l.Menu.childMenus[i]; if (document.layers) { theLayer.visibility =3D "hidden"; } else { theLayer =3D FIND(theLayer); theLayer.style.visibility =3D "hidden"; } theLayer.Menu.hideChildMenu(theLayer); } if (l.childMenu) { var childMenu =3D l.childMenu; if (document.layers) { l.Menu.FW_showMenu(null,null,null,childMenu.layers[0]); childMenu.zIndex =3D l.parentLayer.zIndex +1; childMenu.top =3D l.top + l.parentLayer.top + l.Menu.menuLayer.top + = l.Menu.menuItemHeight/3; if (childMenu.left + childMenu.clip.width > window.innerWidth) { childMenu.left =3D l.parentLayer.left - childMenu.clip.width + = l.Menu.menuLayer.left + 15; l.Menu.container.clip.left -=3D childMenu.clip.width; } else { childMenu.left =3D l.parentLayer.left + l.parentLayer.clip.width + = l.Menu.menuLayer.left -5; } var w =3D = childMenu.clip.width+childMenu.left-l.Menu.container.clip.left; if (w > l.Menu.container.clip.width) =20 l.Menu.container.clip.width =3D w; var h =3D = childMenu.clip.height+childMenu.top-l.Menu.container.clip.top; if (h > l.Menu.container.clip.height) l.Menu.container.clip.height = =3D h; l.document.layers[1].zIndex =3D 0; childMenu.visibility =3D "inherit"; } else if (FIND("menuItem0")) { childMenu =3D FIND(l.childMenu); var menuLayer =3D FIND(l.Menu.menuLayer); var s =3D childMenu.style; s.zIndex =3D menuLayer.style.zIndex+1; if (document.all) { // ie case. s.pixelTop =3D l.style.pixelTop + menuLayer.style.pixelTop + = l.Menu.menuItemHeight/3; s.left =3D s.pixelLeft =3D (menuLayer.style.pixelWidth) + = menuLayer.style.pixelLeft -5; } else { // zilla case var top =3D PxToNum(l.style.top) + PxToNum(menuLayer.style.top) + = l.Menu.menuItemHeight/3; var left =3D (PxToNum(menuLayer.style.width)) + = PxToNum(menuLayer.style.left) -5; s.top =3D top; s.left =3D left; } childMenu.style.visibility =3D "inherit"; } else { return; } window.activeMenus[window.activeMenus.length] =3D childMenu; } } function hideActiveMenus() { if (!window.activeMenus) return; for (var i=3D0; i < window.activeMenus.length; i++) { if (!activeMenus[i]) continue; if (activeMenus[i].visibility && activeMenus[i].Menu) { activeMenus[i].visibility =3D "hidden"; activeMenus[i].Menu.container.visibility =3D "hidden"; activeMenus[i].Menu.container.clip.left =3D 0; } else if (activeMenus[i].style) { var s =3D activeMenus[i].style; s.visibility =3D "hidden"; s.left =3D -200; s.top =3D -200; } } if (window.ActiveMenuItem) { hideMenu(false, false); } window.activeMenus.length =3D 0; } ------=_NextPart_000_0000_01C87AC7.F32025B0--